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Anxiety and stress in dogs: natural approach

What does science say about herbs and CBD for anxiety in dogs? Honest overview of evidence, safety and when to see a vet.

Weak evidenceOnly small, uncontrolled or indirect studies (e.g. an animal model or extrapolation from humans). Uncertain; treat claims with caution.
Published: Last updated: Next review: 27 June 20272 min read

Short & honest

Valerian and CBD have been studied for dog anxiety, but studies are too small and short-term for firm conclusions — evidence grade C (weak).

Veterinary review not yet completed

This page is awaiting review by a registered veterinary surgeon. Until then, treat the text as education based on the sources listed — not as a verified veterinary judgement.

What is anxiety and stress in dogs?

Anxiety in dogs manifests in various ways: trembling, panting, hiding, destructive behaviour, excessive barking or restlessness in response to triggers such as separation, car travel, thunderstorms or unfamiliar environments. Chronic stress lowers quality of life and can exacerbate behavioural problems.

The approach with the greatest scientific weight is a combination of behaviour therapy and — in severe cases — veterinary medication. Supplementary products may be used supportively in consultation with a veterinary surgeon, but do not replace professional guidance.


What does the evidence say?

Valerian

Valerian (Valeriana officinalis) is traditionally used as a calming herb. A narrative review combined animal studies and questionnaire research in dogs and found positive signals for calmer behaviour [1]. A separate clinical assessment concluded, however, that evidence in pets largely remains limited to anecdotes and extrapolation from human research, without controlled studies of sufficient size [2].

Verdict: C — weak evidence, further controlled research lacking.

CBD (cannabidiol)

Two randomised controlled trials (RCTs) investigated CBD in dogs:

  • After a single CBD dose, fewer stress-related behaviours were measured in separation anxiety and car travel [3].
  • In a standardised sound anxiety test, no statistically significant effects on anxiety symptoms were found [4].

The outcomes are thus mixed. Both studies are small and short-term. Which formulations, populations and circumstances yield an effect — and how large that effect is — remains unclear. Adverse effects in these studies were mild, but long-term safety has not been investigated in dogs.

Verdict: C — mixed and preliminary evidence, methodologically limited.


Overview per option

ProductEvidenceRemark
ValerianC – weakLittle controlled research in dogs [1][2]
CBDC – mixedPositive in separation/travel [3], not in sound anxiety [4]

Safety and points of attention

  • CBD products for animals fall under the Commodities Act (Warenwet) in the Netherlands. Quality and purity of freely available products vary greatly; THC content must remain below the legal limit.
  • Valerian is considered relatively safe at low doses, but is not registered as a veterinary medicinal product in the Netherlands.
  • Both products are no substitute for behaviour therapy or veterinary medication in moderate to severe anxiety.
  • Always consult a veterinary surgeon before use, especially in dogs already using medication — interactions are possible (see below).

When to go to the veterinary surgeon immediately?

Moderate to severe anxiety occurring daily, leading to self-injury or resulting in aggressive behaviour requires professional behavioural guidance. Supplementary products are not a first step and provide insufficient support as the sole intervention.

Why this verdict?

The available literature consists of two small RCTs on CBD [3][4] with mixed outcomes, and a narrative review combining valerian with other agents without placebo control [1][2]. Studies are short-term, methodologically limited and show no consistent effects — sufficient for grade C (weak, preliminary evidence), insufficient for clinical recommendations.

How we grade evidence →

Interactions with medication

  • CBD may interact with medicines metabolised via the cytochrome P450 system, including certain antiepileptics, analgesics (NSAIDs) and cardiac medication — consultation with a veterinary surgeon is mandatory
  • Valerian may enhance the sedative effect of other calming agents or anaesthesia

Legal status (Netherlands)

In the Netherlands, CBD products for animals fall under the Commodities Act (Warenwet) and may not legally make medical or health claims. The THC content must remain below the legal limit. Treatment of behavioural problems in animals is reserved to veterinary surgeons in the Netherlands (Animals Act [Wet Dieren], Article 2.10).

Sources

  1. [1] Multimodal assessment of Hericium erinaceus and Valeriana officinalis for canine anxiety: EEG, neurochemical analysis, and behavioral surveys. Journal of Veterinary Behavior (ScienceDirect), 2025. Narrative review source ↗
  2. [2] Is Valerian effective against stress in pets? - Vet Help Direct. Vet Help Direct, 2021. Narrative review source ↗
  3. [3] A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel. Frontiers in Veterinary Science, 2023. RCT doi:10.3389/fvets.2023.1112604
  4. [4] The Impact of Feeding Cannabidiol (CBD) Containing Treats on Canine Response to a Noise-Induced Fear Response Test. Frontiers in Veterinary Science (Morris EM et al.), 2020. RCT doi:10.3389/fvets.2020.569565

Written by Redactie Diernatuur Wiki

Independent editorial team

An independent editorial team that gathers the literature, grades the evidence and writes according to the editorial charter. Sells nothing and has no commercial interests.

  • Works to a GRADE-style evidence rating
  • No commercial interests